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11,314

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4

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BETA-LACTAMASE

Categories

Table of contents

CHAPTER ONE

1.1      Evolution of B-lactamase

1.2      Origin & Spread b-lactamases

1.3      Classification of b-lactamases

1.4      Characterization and types of ESBLs

1.5      Factors Influencing b-lactamases Expression

1.6      Genetics of b-lactamases

CHAPTER TWO

2.1      Epidemiology of b-lactamases

2.2      Epidemiology of b-lactamase Across the Continent

2.2.1   Europe

2.2.2   South and Central America

2.2.3   North America

2.2.4   Africa

2.2.5   Middle East

2.2.6   Australia

2.2.6   Asia

CHAPTER THREE

3.1      Methods of detection

3.1.1   Screening tests

CHAPTER FOUR

TREATMENT AND CONTROL MEASURES

4.1      Treatment

4.2      Control measures

Conclusion

REFERENCES

Abstract

The b-lactamases are the major defense of gram-negative bacteria against b-lactam antibiotics. b-lactamases can be broadly divided into enzymes with a serine residue at the active site, similar to bacterial penicillin binding proteins, from which they probably evolved, and metalloenzymes with zinc ion as a cofactor and with a separate heritage. Both are ancient enzymes. The serine group is estimated from current sequence diversity to have evolved with bacteria over the past 2 billion years.

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