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BETA-LACTAMASE
Categories
Table of contents
CHAPTER ONE
1.1 Evolution of B-lactamase
1.2 Origin & Spread b-lactamases
1.3 Classification of b-lactamases
1.4 Characterization and types of ESBLs
1.5 Factors Influencing b-lactamases Expression
1.6 Genetics of b-lactamases
CHAPTER TWO
2.1 Epidemiology of b-lactamases
2.2 Epidemiology of b-lactamase Across the Continent
2.2.1 Europe
2.2.2 South and Central America
2.2.3 North America
2.2.4 Africa
2.2.5 Middle East
2.2.6 Australia
2.2.6 Asia
CHAPTER THREE
3.1 Methods of detection
3.1.1 Screening tests
CHAPTER FOUR
TREATMENT AND CONTROL MEASURES
4.1 Treatment
4.2 Control measures
Conclusion
REFERENCES
Abstract
The b-lactamases are the major defense of gram-negative bacteria against b-lactam antibiotics. b-lactamases can be broadly divided into enzymes with a serine residue at the active site, similar to bacterial penicillin binding proteins, from which they probably evolved, and metalloenzymes with zinc ion as a cofactor and with a separate heritage. Both are ancient enzymes. The serine group is estimated from current sequence diversity to have evolved with bacteria over the past 2 billion years.
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