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RESISTANCE MECHANISM OF BACTERIA AGAINST VANCOMYCIN

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Table of contents

CHAPTER ONE                                                                                                        1

1.0       Introduction                                                                                                    1

1.1       Vancomycin                                                                                                    2

CHAPTER TWO: Literature Review                                                                         4

2.1       Antibiotic Resistance                                                                                      4

2.2       Glycopeptides                                                                                                 5

2.3       The Importance of Vancomycin                                                                     6

2.4       Mode of Action of Vancomycin                                                                    8

2.5       Resistance Development to Vancomycin                                                       9

2.6       Mechanism of Vancomycin Resistance                                                          10

CHAPTER THREE                                                                                                    15

3.1       Vancomycin Resistance in Enterococcus                                                       15

3.1.1    Glycopeptides Resistance in Enterococci                                                       15

3.1.2    The van Resistance Genetic Determinants of Enterococcal spp.                   16

3.1.3    Phenotype versus Genotype Expression of Vancomycin Resistance in Clinical 

            Enterococcal Species                                                                                      18

3.2       Vancomycin Resistance in Staphylococus aureus                                          19

3.2.1    Vancomycin Intermediate S. aureus (VISA)                                                 20

3.2.2    Vancomycin-Resistant S. aureus (VRSA)                                                      21

3.3       Vancomycin Resistance in Streptococcus Pneumonaie                                  22

3.4       Adverse Effect of Vancomycin Resistance                                                    23

CHAPTER FOUR                                                                                                      25

4.1       Control of Vancomycin Resistance                                                                25

4.2       Current Therapeutics in Treatment of Vancomycin Resistance Infection      28

4.3       Alternative Therapy for Vancomycin                                                             29

CHAPTER FIVE                                                                                                       32

5.0       Conclusion                                                                                                      32

References                                                                                                                  34

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