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CURRENT TRENDS OF EXTENDED-SPECTRUM BETA-LACTAMASES PRODUCING MICROORGANISMS
Categories
Table of contents
CHAPTER ONE 1
1.0 Introduction 1
CHAPTER TWO 5
2.1 Extended-spectrum 𝛽-lactamases 5
2.2 Beta Lactams 7
2.3 Classification of Beta-Lactamases 7
2.3.1 Group I (Ambler Class C) beta-lactamases (also known as AmpC enzymes). 8
2.3.2 Group 2 (Ambler Class A) enzymes 8
2.3.3 Group 3 (Ambler Class B) enzymes 9
2.4 Types of ESBLs 9
2.5 ESBL Producing Organisms 11
2.5.1 Enterobacteriaceae 11
2.5.2 E.coli and Klebsiella species 14
2.5.3 Pseudomonas aeruginosa 16
2.5.4 Acinetobacter Species 17
2.6 Prevention and Control Management of ESBL 17
2.7 Treatment and Management of ESBL Infection 18
CHAPTER THREE 20
3.1 Risk Factors for Colonization and Infection with Extended Spectrum Beta-
lactamase Producers 20
3.2 Risk Factors for Extended Spectrum Beta-lactamase Acquired in Adults 22
3.3 Risk Factors for Extended Spectrum Beta-lactamase Acquired in Children 22
3.4 Dissemination of ESBL 24
3.4.1 Clonal expansion 24
3.4.2 Horizontal dissemination 26
3.5 Persistence of ESBL 27
CHAPTER FOUR 29
4.0 Epidemiology of Extended Spectrum Lactamase 29
4.1 Epidemiology of Extended Spectrum Lactamase in South and Central America 29
4.2 Epidemiology of Extended Spectrum Lactamase in North America 29
4.3 Epidemiology of Extended Spectrum Lactamase in Europe 30
4.4 Epidemiology of Extended Spectrum Lactamase in Africa 32
4.5 Epidemiology of Extended Spectrum Lactamase in Middle East 33
4.6 Epidemiology of Extended Spectrum Lactamase in Australia 34
4.7 Epidemiology of Extended Spectrum Lactamase in Asia 34
CHAPTER FIVE 37
Conclusion 37
References 40
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