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BACTERIA TOXINS AND THEIR MODES OF ACTIONS

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Table of contents

CHAPTER ONE                                                                                                         1

1.1       Introduction                                                                                                    1

1.2       Historical Perspective of Bacterial Toxin                                                      2

CHAPTER TWO                                                                                                        5

2.1       Toxins as Unique Enzymes with Complex Architecture                               5

2.2       Shiga toxins and other bacterial toxins                                                          6

CHAPTER THREE                                                                                                    12

3.1       Mode of Action of Bacteria Toxin                                                                 12

3.2       Toxins Targeting Actin and Small Rho Gtpases                                            12

3.3       Toxins Corrupting Ubiquitin and Ubiquitin-Like Signaling                          15

3.4       Toxins Targeting Cell Translational Machinery                                            16

3.5       Toxins Targeting Snare Machinery                                                                17

3.6       Toxins Targeting DNA and Inducing ER Stress Responses                          19

3.7       Toxins Targeting cAMP Signaling Components                                           19

 

CHAPTER FOUR                                                                                                      22

4.0       Toxin Therapeutics                                                                                         22

4.1       Bacterial Protein Toxins as Toxoid Vaccine                                                  22

4.2       Role of Toxin as Immunotoxins in Treatment of Cancer                               22

4.3       Diphtheria Toxin (DT) Based Immunotoxin                                                  23

4.4       Pseudomonas Exotoxin A-based Immunotoxins                                           24

4.5       Anthrax Toxin Based Immunotoxins                                                             24

4.6       Botulinum Toxin Based Therapeutics                                                            25

4.6.1    Dermatological use of Botulinum toxin:                                                        25

4.6.2    Non-dermatological use of Botulinum toxin:                                                 26

4.3       Conclusion                                                                                                      27

REFERENCES                                                                                                           30

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