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CAMPYLOBACTER INFECTION: TREATMENT, CONTROL AND PREVENTION
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Table of contents
CHAPTER ONE 1
1.1 Overview of the Genus Campylobacter 1
1.2 Campylobacter Historical Perspective 2
1.3 Pathogenesis 3
1.4 Etiology and Transmission 5
1.5 Campylobacter Ecology 6
1.5.1 Survival in the Environment 6
1.5.2 Animal Sources 7
1.5.3 Food and Water Sources 9
CHAPTER TWO 11
2.1 Epidemiology 11
2.2 Campylobacter Contamination of Food of Animal Origin 15
2.3 Detection Techniques 16
2.3.1 Sample Preparation and Processing 16
2.3.2 Surface Rinse Technique 17
2.3.3 Swab Technique 17
2.3.4 Recognition of Colonies 17
2.3.5 Confirmatory Tests 18
CHAPTER THREE 19
3.1 Clinical Presentation 19
3.2 Post-infectious Complications 20
3.3 Diagnosis 23
CHAPTER FOUR 24
4.1 Treatment of Campylobacteriosis 24
4.2 Control and Prevention 26
REFERENCES 29
Abstract
Bacteria belonging to the genus Campylobacter are Gram-negative, spiral, non-spore forming rods that form spherical or coccoid bodies in older cultures. Campylobacter and Archobacter are between 0.2 to 0.9 microns wide and 0.5 to 5 microns long, are motile and usually move with a polar unsheathed flagellum at one or both ends, and are microaerobic with a respiratory-type metabolism, although there are some that grow aerobically or anaerobically. The sequence of the genome of Campylobacter jejuni NCTC11168 was originally published in 2000. There is considerable variation between strains and re-annotation of the C. jejuni genome published in 2006 revealed that the complete sequence is 1,641,481 bp in length with 25 polymorphic regions. Moreover, new information for 1,450 of the original 1,654 coding sequences revealed changes corresponding to over 300 product functions. The infectious diseases caused by members of the bacterial genus Campylobacter are called campylobacteriosis. Currently Campylobacter jejuni and Campylobacter coli are considered to be the most important enteropathogens among Campylobacter spp. The rate of Campylobacter infections are increasing worldwide, exceeding shigellosis.
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