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GLOBAL BURDEN OF Mycobacterium tuberculosis AND DISEASE RESISTANCE

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Table of contents

CHAPTER ONE                                                                                            1

1.1       Introduction                                                                                        1

CHAPTER TWO                                                                                            4

2.1       Ecology of Mycobacteria tuberculosis                                                4

2.2       Prevalence of Mycobacteria tuberculosis across the World                7

2.3       Prevalence of Mycobacteria tuberculosis in Nigeria                           9

2.4       Spread of Tuberculosis                                                                       10

2.5       An exemplary Model of Adaptation of M. tuberculosis to humans   13

CHAPTER THREE                                                                                        18

3.1       Drug Resistance in Mycobacteria tuberculosis                                   18

3.2       Mechanism of Drug Resistance in Mycobacteria tuberculosis           20

3.2.1    Mechanism of Resistance to First line Drugs                                     21

3.2.2    Mechanism of Resistance to Second line Drugs                                 25

3.2.3    Mechanisms of Resistance to Newly and Repurposed Drug             27

3.3       Burden of Drug Resistance Mycobacteria tuberculosis                      27

CHAPTER FOUR                                                                                          30

4.1       Control and Prevention of Mycobacteria tuberculosis                       30

4.2       Treatment and Vaccines of Mycobacteria tuberculosis                      33

4.3       Management of Anti-Tuberculosis Drug Resistance                          36

4.4       Conclusion                                                                                          38

References                                                                                                      40

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