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MICROBIAL TOXINS AND THEIR MODE OF ACTIONS

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Table of contents

 

CHAPTER ONE 

1.1       Introduction 

CHAPTER TWO 

2.1       Toxins as Unique Enzymes with Complex Architecture 

2.2       Shiga toxins and other bacterial toxins 

CHAPTER THREE 

3.1       Mode of Action of Bacteria Toxin 

3.2       Toxins Targeting Actin and Small Rho Gtpases 

3.3       Toxins Corrupting Ubiquitin and Ubiquitin-Like Signaling 

3.4       Toxins Targeting Cell Translational Machinery 

3.5       Toxins Targeting Snare Machinery 

3.6       Toxins Targeting DNA and Inducing ER Stress Responses 

3.7       Toxins targeting cAMP Signaling Components 

CHAPTER FOUR 

Toxin Therapeutics 

4.1       Bacterial Protein Toxins as Toxoid Vaccine 

4.2       Role of Toxin as Immunotoxins in Treatment of Cancer 

4.3       Diphtheria Toxin (DT) Based Immunotoxin 

4.4       Pseudomonas Exotoxin A-based Immunotoxins 

4.5       Anthrax Toxin Based Immunotoxins 

4.6       Botulinum Toxin Based Therapeutics 

4.6.1    Dermatological use of Botulinum toxin: 

4.6.2    Non-dermatological use of Botulinum toxin 

CONCLUSION 

REFERENCES 

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