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BURULI ULCER IN AFRICA – ITS EPIDEMIOLOGY

Table of contents

CHAPTER ONE                                                                                        1

1.1      Introduction: Buruli Ulcer                                                                1

1.2      Brief History of Buruli Ulcer                                                            1

1.3      Causative Organism and Pathology                                                   2

1.4      Clinical Presentation of Buruli Ulcer                                                3

CHAPTER TWO                                                                                       8

2.1      Epidemiology of Buruli Ulcer in Africa                                            8

2.2      Buruli Ulcer in Central Republic of Africa                                        9

2.3      Buruli Ulcer in Nigeria                                                                     11

CHAPTER THREE                                                                                    14

3.1      Recent Research on Transmission of Buruli Ulcer                             14

3.2      Differential Diagnoses of Buruli Ulcer                                              15

3.3      Diagnosis of Buruli Ulcer                                                                 16

CHAPTER FOUR                                                                                      18

4.1      Treatment of Buruli Ulcer                                                                18

4.2      Monitoring and Prognosis                                                                20

4.3      Prevention                                                                                       21

References                                                                                                 23

 LIST OF FIGURES

FIGURE           TITLE                                                                             PAGE

1A:              Initial nodular lesion of Buruli Ulcer                                                  6

1B.               Small ulcerated lesions                                                                    6

1C.               Large ulcerated lesion with undermined borders                               7

Abstract

Buruli ulcer is a disabling skin infection caused by Mycobacterium ulcerans. It was first named as Buruli in Uganda, a region where many of the early cases in the literature were described. Buruli ulcer begins as localized skin lions that progress to extensive ulceration, leading to functional disability, loss of economic productivity, and social stigma. Since the 1998 World Health Organization (WHO) Buruli ulcer initiative, there has been increased attention to research efforts for treatment and control of Buruli ulcer. Buruli ulcer is a disease of skin and soft tissue with the potential to leave sufferers scarred and disabled. It is caused by an environmental pathogen, Mycobacterium ulcerans that produces a destructive toxin. The main burden of disease falls on children living in sub-Saharan Africa, but healthy people of all ages, races, and socioeconomic classes are susceptible.

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