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MYCOBACTERIUM TUBERCULOSIS AND ANTIBIOTIC RESISTANCE

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CHAPTER ONE                                                                                                                    1

1.1       Introduction                                                                                                                1

CHAPTER TWO                                                                                                                    6

2.1       Biology of Mycobacteria tuberculosis                                                                        6

2.2       Mycobacteria tuberculosis in History                                                                         8

2.3       Epidemiology of Mycobacteria tuberculosis                                                              9

2.4       Transmission of Tuberculosis                                                                                      11

2.5       Symptoms of Mycobacteria tuberculosis                                                                    14

CHAPTER THREE                                                                                                                17

3.1       Drug Resistance in Mycobacteria tuberculosis                                                           17

3.2       Evolution of Drug Resistance in Mycobacteria tuberculosis                                      18

3.3       Mechanism of Drug Resistance in Mycobacteria tuberculosis                                   19

3.3.1    Mechanism of Resistance to First line Drugs                                                             20

3.3.2    Mechanism of Resistance to Second line Drugs                                                         24

3.3.3    Mechanisms of Resistance to Newly and Repurposed Drug                                     26

3.4       Threats of Drug Resistance Mycobacteria tuberculosis                                              26

CHAPTER FOUR                                                                                                                  29

4.1       Control and Elimination of Mycobacteria tuberculosis                                              29

4.2       Treatment and Vaccines of Mycobacteria tuberculosis                                              30

4.3       Management of Anti-Tuberculosis Drug Resistance                                                  32

4.4       Prevention of Drug Resistance Tuberculosis                                                              34

CHAPTER FIVE: CONCLUSION                                                                                       38

References                                                                                                                                                                         40 

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